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The Beta Blocker and Clonidine Protocol

Lesson 5

2. Clonidine: Wallace

The clonidine study is very similar to the atenolol study. Prospective, randomized, double blinded, placebo controlled, clinical trial in 200 patients undergoing non-cardiac surgery at the VA. Clonidine 0.2 mg PO as well as a Clonidine TTS-2 patch (0.2 mg per day transcutaneous) were applied the night before surgery (or placebo patch and pills). On the morning of surgery another clonidine 0.2 mg PO tablet (or placebo) was administered. The clonidine patch (or placebo patch) was continued for 4 days. ECG, Holter, CPK-MB, Computerized blood pressure recordings, visual analogue (VAS) pain scores, catecholamine levels, daily examinations and long term follow-up were performed.

Effect of clonidine on cardiovascular morbidity and mortality after noncardiac surgery.
Anesthesiology 2004; 101: 284-93
Wallace, Galindez et al.

bullet Randomized, Placebo Controlled, Double Blinded Clinical Trial in 200 patients with or at risk for CAD undergoing non-cardiac surgery.
bullet Clonidine 0.2 mg po night before, 0.2 mg po day of, and 0.2 mg TTS-2 patch for 4 days. Vs placebo pills and patch
bullet ECG, Holter ECG, CPK-MB, Computerized BP recording, VAS pain scores, catecholamines, H&P
bullet Long Term Follow-up

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Content by Art Wallace MD PhD
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