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The Beta Blocker and Clonidine Protocol

Lesson 4
Lesson 4 - Beta Blockers

2. The Atenolol Study

What is the basis for this recommendation? Mangano et. al. in the Effect of atenolol on mortality and cardiovascular morbidity after noncardiac surgery. N Engl J Med 1997 did a prospective, randomized, double blinded, placebo-controlled clinical trial in 200 patients They did H&P, ECG's, Holter monitoring, CPK with MB, hemodynamics, and then looked to see what happened.

Atenolol Study.

bullet Randomize, Double Blinded, Placebo Controlled, Clinical Trial in 200 patients
bullet H&P, Holter ECG for 7 Days, ECG q Day, CPK with MB, Hemodynamic
  • Incidence and Severity of ST changes on Holter
  • Hemodynamics
  • Safety (Death, MI, CHF, Broncospasm, Unstable angina, Dysrhythmias)
  • Hospital D/C, 2 Year, 5 Year Followup


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